Nitrogen (N) deposition can alter belowground microbial communities, especially ectomycorrhizal (ECM) fungi, resulting in a reduced ability of associated trees to access organic nutrients. This study tested whether N addition decreases ECM species richness and shifts ECM species composition across spatial scales in a subtropical slash pine (Pinus elliottii) plantation...
The vertebrate brain, which is made up of a vast array of individual neurons, is responsible for controlling numerous functions and behaviors, including distinguishing between visual cues, learning to navigate in a new environment, or making complex decisions. These neurons form specific networks that receive, process, and integrate chemical and...
Fusion of biological membranes is dictated by the interaction between specialized membrane proteins and the lipid bilayer. Parainfluenza virus 5 (PIV5) mediates fusion using two surface glycoproteins: the fusion protein (F) and the attachment protein hemagglutinin-neuraminidase (HN). Activation of membrane fusion of PIV5 typically occurs at neutral pH, and involves...
The genetic information in DNA is transcribed to mRNA and then translated to proteins, which form the building blocks of life. Translation, or protein synthesis, is hence a central cellular process. Decades of experimentation have elucidated a vast wealth of molecular information about discrete translation steps, but the sheer complexity...
Assembly of the large and small subunits of the <em>E. coli</em> ribosome is a complicated process that involves transcription, processing, and modifying of the ribosomal RNA, the binding of ribosomal proteins, and the folding of the particles into complex structures. A number of ribosome assembly factors, including maturation factors, GTPases,...
The promise of a clean, renewable, and abundant energy supply make the efficient conversion of solar energy to electricity a compelling scientific and societal goal. In the following chapters, I will describe my efforts to advance one class of photovoltaic technology, dye-sensitized solar cells, by demonstration and characterization of unexplored...
Polarized epithelial cells are divided by tight junctions into an apical membrane domain, which faces the lumen of an organ, and a basolateral domain, which is in contact with underlying connective tissues. To establish and maintain polarity, newly synthesized and recycling transmembrane proteins are sorted to either the apical or...
On 6 February 2007, President Bush announced that the United States would
create a new military command for Africa, to be known as Africa Command or Africom.
Throughout the Cold War and for more than a decade afterwards, the U.S. did not have a
military command for Africa; instead, U.S....
Inflammasomes are signaling complexes that link the recognition of pathogen and danger associated molecular patterns (PAMPs and DAMPs) by cytosolic pattern-recognition receptors (PPRs) to the activation of Caspase-1, leading to the release of the pro-inflammatory cytokines interleukin (IL)-1 and IL-18, and the induction of pyroptosis. In addition to the canonical...
Coronary magnetic resonance angiography (MRA) is emerging as a promising method for noninvasive diagnosis of coronary artery diseases. Nonetheless, acquisition of large-coverage high-resolution coronary artery images requires free-breathing acquisition. Accurately measuring and correcting respiratory motion has been one of the major challenges to coronary MRA. Diaphragmatic navigator (NAV), the current...