The speed of the storage device has long lagged behind the computation speed of processors.As a result, the I/O performance of storage systems in a supercomputer fails to keep up with its computational power.
This gap continues to widen in modern supercomputers.
On future exascale supercomputers, this issue can worsen...
Soft materials are inherently fluxional, with morphologies and behaviors that are dictated by their solvation state. Thus, many organic systems cannot be reliably imaged by static dry state or cryogenic-transmission electron microscopy (TEM). This motivated us to pursue liquid cell (LC) TEM method development to study our own materials and...
CD95/Fas ligand (CD95L) is a well characterized activator of extrinsic apoptosis. CD95L protein binds to its cognate receptor, CD95/Fas/APO-1, inducing apoptotic signaling in sensitive cells. However, expression of CD95L is toxic even in the absence of CD95. We previously reported that the CD95L open reading frame (ORF) is enriched for...
Task-oriented conversational systems are becoming increasingly popular, as shown by the rise of conversational recommendation systems across multiple platforms (e.g., Google Home, Alexa, and Siri) and domains (e.g., local establishments, e-commerce, books, music, and movies). However, users are still largely limited in what preferences they can express and how, as...
Aging is the greatest known risk factor for Alzheimer’s Disease (AD); however, the molecular mechanisms underlying aging and how it can initiate and or exacerbate AD, is still unknown. Epigenetic regulation has been widely accepted to play an essential role in aging or AD-related processes; however, whether dysregulations of histone...
Human olfactory function is important for a myriad of behaviors, including food seeking, social cognition, memory, emotional regulation, and detecting environmental threats. In animal models, particularly dense olfactory inputs have been shown to target orbitofrontal cortex (OFC), a region involved in multimodal sensory integration, reward coding, and flexibly guiding our...
We establish the criterion for chaos in three-planet systems, for systems similar to those discovered by the Kepler spacecraft. Our main results are as follows: (i) The simplest criterion, which is based on overlapping mean motion resonances (MMRs), only agrees with numerical simulations at a very crude level. (ii) Much...
Since Infrared radiation was discovered in 1800s, the research and applications on the infrared regime have been continually developed. The infrared detectors are the key technology in these applications and have been successfully used for medical imaging, light detection and ranging (LiDAR), free-space optical communication, target tracking and object identification...
As machines take over the work of producing, organizing, and curating culture, it becomes increasingly important to examine the influence of algorithms in public memory work, through which the past is selectively and subjectively reconstructed to make meaning in the present. Accordingly, this dissertation intervenes at the intersection of public...
A fundamental materials science question is “why and how will this material form?” The experimental,computation, and time resources necessary to answer this question consume significant resources due to the
predominantly trial-and-error based approaches common in materials research. This dissertation reintroduces
a number of fundamental thermodynamics-based tools for the study of...