The speed of the storage device has long lagged behind the computation speed of processors.As a result, the I/O performance of storage systems in a supercomputer fails to keep up with its computational power.
This gap continues to widen in modern supercomputers.
On future exascale supercomputers, this issue can worsen...
Visual processing often requires the coordination of different neurophysiological regions in the visual system to independently represent and then re-integrate the different features of an object to gain an accurate and coherent representation of that object. Yet, under certain circumstances, this process can go awry and result in illusory misbindings,...
This dissertation considers how women’s spectatorship—how women are imagined as viewing subjects, and what are defined as feminine ways of watching—is transformed by digital technologies, and what it reveals about the shifting nature of privacy and visibility. It maps the contours of our current configuration of gendered looking relations by...
Task-oriented conversational systems are becoming increasingly popular, as shown by the rise of conversational recommendation systems across multiple platforms (e.g., Google Home, Alexa, and Siri) and domains (e.g., local establishments, e-commerce, books, music, and movies). However, users are still largely limited in what preferences they can express and how, as...
We establish the criterion for chaos in three-planet systems, for systems similar to those discovered by the Kepler spacecraft. Our main results are as follows: (i) The simplest criterion, which is based on overlapping mean motion resonances (MMRs), only agrees with numerical simulations at a very crude level. (ii) Much...
Human olfactory function is important for a myriad of behaviors, including food seeking, social cognition, memory, emotional regulation, and detecting environmental threats. In animal models, particularly dense olfactory inputs have been shown to target orbitofrontal cortex (OFC), a region involved in multimodal sensory integration, reward coding, and flexibly guiding our...
Relative to individual level exposures (such as childhood trauma, life events, and bullying exposure), contextual or systems level environmental factors have received relatively less attention in the psychology literature. While landmark epidemiological and sociological studies have uncovered key insights with regards to systems, this knowledge has not often been translated...
Soft materials are inherently fluxional, with morphologies and behaviors that are dictated by their solvation state. Thus, many organic systems cannot be reliably imaged by static dry state or cryogenic-transmission electron microscopy (TEM). This motivated us to pursue liquid cell (LC) TEM method development to study our own materials and...
CD95/Fas ligand (CD95L) is a well characterized activator of extrinsic apoptosis. CD95L protein binds to its cognate receptor, CD95/Fas/APO-1, inducing apoptotic signaling in sensitive cells. However, expression of CD95L is toxic even in the absence of CD95. We previously reported that the CD95L open reading frame (ORF) is enriched for...
Aging is the greatest known risk factor for Alzheimer’s Disease (AD); however, the molecular mechanisms underlying aging and how it can initiate and or exacerbate AD, is still unknown. Epigenetic regulation has been widely accepted to play an essential role in aging or AD-related processes; however, whether dysregulations of histone...