Index Catalog // Arch : Northwestern University Institutional Repository

Ets1 Regulation of the Small Heat Shock Protein alphaB-Crystallin and Involvement in Breast Cancer Cell Transformation

Description:: The small heat shock protein αB-crystallin is expressed primarily in lens and muscle tissue, but it is also found in lung, kidney and many cancers. Regulators of αB-crystallin have been identified almost exclusively using mouse muscle and lens specific models. It has been well documented that αB-crystallin is expressed in...
Keyword:: Molecular Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Joshua Bosman
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/31/2018
Date Modified:: 08/31/2018
Date Created:: 2008-04-24
Resource Type:: Dissertation

Development of Alveolar Epithelial Type II Cell-Specific Nuclear Targeting Vectors for Gene Therapy

Description:: Although non-viral gene therapy has great potential for use in the lung, several problems including inefficient gene transfer and expression and the relative lack of cell-specific targeting have limited its applications. The two approaches that have been used to target genes to desired cell types are through specific ligand-receptor interactions...
Keyword:: nuclear import, SP-C, gene therapy, plasmid, and non-viral
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: James Vincent DeGiulio
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/16/2018
Date Modified:: 08/16/2018
Date Created:: 2007-09-24
Resource Type:: Dissertation

Structural and Conformational Requirements of Membrane Fusion Mediated by the Parainfluenza Virus 5 Fusion Protein

Description:: Fusion of biological membranes is dictated by the interaction between specialized membrane proteins and the lipid bilayer. Parainfluenza virus 5 (PIV5) mediates fusion using two surface glycoproteins: the fusion protein (F) and the attachment protein hemagglutinin-neuraminidase (HN). Activation of membrane fusion of PIV5 typically occurs at neutral pH, and involves...
Keyword:: Class I virus fusion, PIV5, fusion protein, and Membrane fusion
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Mei Lin Bissonnette
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-11-06
Resource Type:: Dissertation

Viral Modulators of Herpesvirus Transport: Insights into Assembly and Transport Regulation

Description:: Herpesviruses require axonal transport for the successful establishment of infection in peripheral ganglia (retrograde transport), and the subsequent spread to exposed body surfaces following reactivation from latency (anterograde transport). Viral progeny are assembled and spread to other tissues or hosts during egress. I focused on viral proteins which modulate directed...
Keyword:: herpes, kinase, axonal transport, assembly, and PRV
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kelly Coller
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/31/2018
Date Modified:: 08/31/2018
Date Created:: 2008-05-06
Resource Type:: Dissertation

Trypanosoma brucei Serine Palmitoyltransferase: Roles In De Novo Sphingolipid Biosynthesis, Life Cycle, and Lipid Raft Formation

Description:: The kinetoplastid protozoan <em>Trypanosoma brucei</em> is the causative agent of African trypanosomiasis, affecting humans, and Nagana disease, affecting cattle, prevalent in regions of sub-Saharan Africa. Our lab demonstrated that the flagellum of <em>T. brucei</em> is enriched in lipid rafts, membrane areas composed of sphingolipids, sterols, and proteins that serve as...
Keyword:: trypanosoma brucei, lipid rafts, trypanosoma, sphingolipids, cell cycle, and serine palmitoyltransferase
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Alina Fridberg
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/31/2018
Date Modified:: 08/31/2018
Date Created:: 2008-02-06
Resource Type:: Dissertation

Dual Regulation of Glucocorticoid-Induced Leucine Zipper (GILZ) by the Glucocorticoid Receptor and Phosphatidylinositol 3-Kinase/AKT Pathways in Multiple Myeloma

Description:: Multiple Myeloma (MM) is an incurable plasma cell malignancy occurring within the bone marrow. Glucocorticoids (GCs) are widely used in the treatment of MM patients due to potent induction of apoptosis. Though known to occur via the glucocorticoid receptor (GR), the molecular details of GC-induced apoptosis in MM cells remain...
Keyword:: Multiple Myeloma, GILZ, AKT, Glucocorticoid, and PI3-kinase
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Katharine M Davies
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/01/2018
Date Modified:: 08/01/2018
Date Created:: 2007-06-17
Resource Type:: Dissertation

Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Description:: Embryonic stem cells have the potential to differentiate into ectodermal, mesodermal and endodermal derivatives. This property makes them a valuable source of tissue specific progenitor and differentiated cells that can be used for cell replacement therapy. The first goal of this thesis is to test if cardiogenesis from embryonic stem...
Keyword:: Cell Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Achuta K Guddati
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/08/2018
Date Modified:: 10/08/2018
Date Created:: 2008-05-09
Resource Type:: Dissertation

Luteinizing Hormone Receptor Signaling Regulates MAP2D Phosphorylation in Preovulatory Granulosa Cells

Description:: The actions of luteinizing hormone (LH) to induce ovulation and luteinization of preovulatory follicles are mediated principally by activation of cAMP-dependent protein kinase (PKA) in granulosa cells. PKA activity is targeted to specific cellular locations by A-kinase anchoring proteins (AKAPs). I previously showed that follicle-stimulating hormone (FSH) induces expression of...
Keyword:: cyloskeleton, MAP2, vimentin, ovary, granulosa cell, and luteinizing hormone
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Maxfield Patrick Flynn
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/03/2018
Date Modified:: 10/03/2018
Date Created:: 2008-08-11
Resource Type:: Dissertation

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Description:: PRC is a PGC-1 coactivator family member responsive to serum growth factors and up regulated in proliferating cells. Unlike PGC-1α and PGC-1β, PRC has not been studied extensively and and its function or regulation remains largely unknown. Both PGC-1α and PGC-1β have been shown to be important regulators of mitochondrial...
Keyword:: Biochemistry and Chemical
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kristel Vercauteren
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/02/2018
Date Modified:: 10/02/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Description:: Early Growth Response genes (Egr1-4) are transcriptional mediators of signals governing growth and differentiation. In sympathetic neuron-derived cell lines, Egr1 is induced by NGF signaling, which is required for sympathetic neuron survival, differentiation and target organ innervation. In the absence of identifiable sympathetic defects in Egr1-deficient mice, we investigated the...
Keyword:: NGF, sympathetic nervous system, and Egr3
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Laurie Christine Eldredge
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

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Ets1 Regulation of the Small Heat Shock Protein alphaB-Crystallin and Involvement in Breast Cancer Cell Transformation

Development of Alveolar Epithelial Type II Cell-Specific Nuclear Targeting Vectors for Gene Therapy

Structural and Conformational Requirements of Membrane Fusion Mediated by the Parainfluenza Virus 5 Fusion Protein

Viral Modulators of Herpesvirus Transport: Insights into Assembly and Transport Regulation

Trypanosoma brucei Serine Palmitoyltransferase: Roles In De Novo Sphingolipid Biosynthesis, Life Cycle, and Lipid Raft Formation

Dual Regulation of Glucocorticoid-Induced Leucine Zipper (GILZ) by the Glucocorticoid Receptor and Phosphatidylinositol 3-Kinase/AKT Pathways in Multiple Myeloma

Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Luteinizing Hormone Receptor Signaling Regulates MAP2D Phosphorylation in Preovulatory Granulosa Cells

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

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