Index Catalog // Arch : Northwestern University Institutional Repository

Structural and Functional Analyses of Herpes Simplex Virus Type1 Glycoproteins B and L, Two Essential Components of the Viral Fusogenic Complex

Description:: Herpes simplex virus (HSV) infection of host cells requires virus attachment to the cell surface and subsequent membrane fusion between the virus envelope and host cell membrane to deliver the nucleocapsid containing the viral genome into the host cell. A proposed mechanism for HSV glycoprotein-induced membrane fusion is gD binding...
Keyword:: Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Erick Lin
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/17/2018
Date Modified:: 09/17/2018
Date Created:: 2008-07-17
Resource Type:: Dissertation

DNA Trafficking in Non-viral Gene Therapy: The Role of the Cytoskeleton

Description:: A primary limitation of non-viral gene therapy is the low level of expression achieved. One of the reasons that higher expression is not achieved is that there are many physical obstacles that prevent the DNA from reaching the nucleus to be expressed. A plasmid must cross the cell membrane, traverse...
Keyword:: Cell Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Erin Elizabeth Vaughan
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/30/2018
Date Modified:: 08/30/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

Inhibits Prostate Cancer Cell Motility through Activation of ALK2-Smad1 Signaling

Description:: Prostate cancer (PCa) is the most commonly diagnosed cancer (1:6), and the second most common cause of cancer-related deaths in American men (>27,000/year). Metastasis is largely responsible for these deaths. During metastasis, tumor cells travel from the prostate to a distant organ where they establish a secondary tumor. Cell motility...
Keyword:: Health Sciences
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Clarissa Schumacher Craft
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/01/2018
Date Modified:: 08/01/2018
Date Created:: 2007-07-27
Resource Type:: Dissertation

Mechanisms of Oxygen Sensing and Hypoxic Increase in Replicative Lifespan

Description:: The response to reduced levels of oxygen (hypoxia) is essential for embryonic development by promoting the proper formation of vascular networks. Conversely, hypoxia also promotes the development of pathophysiological processes such as pulmonary hypertension and cancer. The main mediator of responses to hypoxia within the cell is the transcription factor...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Eric Bell
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/01/2018
Date Modified:: 08/01/2018
Date Created:: 07-27-2007
Resource Type:: Dissertation

Estrogen Neuroendocrine Feedback is Mediated Distinctly via Estrogen Response Element Dependent and Independent Estrogen Receptor Alpha Signaling

Description:: Gonadotropins LH and FSH are secreted by the pituitary in response to hypothalamic GnRH and act to stimulate ovarian follicle development, steroid production and ovulation. Gonadal steroids, including estrogen, enter the circulation and provide neuroendocrine feedback at the hypothalamus and/or pituitary. Estrogen provides negative feedback to suppress gonadotropin release throughout...
Keyword:: Neuroendocrinology, Non-classical, Estrogen, Classical, Nonclassical, and Reproduction
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Christine Ann Glidewell-Kenney
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/14/2018
Date Modified:: 09/14/2018
Date Created:: 2008-07-15
Resource Type:: Dissertation

Stat3-Dependent Survival and Stat3-Independent Terminal Differentiation in the B Cell Compartment in IL-6 Transgenic Mice

Description:: IL-6 is a pleiotropic cytokine involved in both immune and non-immune functions. In the immune system, IL-6 induces terminal differentiation of B cells into plasma cells, thereby promoting antibody production. IL-6 stimulates growth of T cells by enhancing the expression of the IL-2 receptor, and IL-6 also causes differentiation of...
Keyword:: Health Sciences
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Sarah E Staggs
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/30/2018
Date Modified:: 08/30/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

N-cadherin Function in Cell Fate Specification of Cortical Precursor Cells

Description:: Cellular interactions are important for the development and maintenance of tissue structural integrity. In the developing neuroepithelium, the adherens junction proteins, N-cadherin and β-catenin, are highly enriched at the apical surface of the proliferative ventricular zone and have been suggested to have critical functions in ensuring the proper development of...
Keyword:: cell fate specification, mitotic division symmetry, beta-catenin, N-cadherin, cortical precursor, and cell adhesion
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Stephanie Noles
Owner:: Jason Christ Chandra
Date Uploaded:: 08/30/2018
Date Modified:: 08/30/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

Dual Mechanisms for Antigen-Specific Peripheral Tolerance Induction as a Therapy for Experimental Autoimmune Encephalomyelitis

Description:: MHC class II-restricted T cell responses are a common driving force of autoimmune disease. Numerous therapeutic strategies target CD4+ T cells hoping to attenuate autoimmune responses and restore self-tolerance. We have previously reported that i.v. treatment with antigen-pulsed, ethylenecarbodiimide (ECDI)-fixed splenocytes (Ag-SP) is an efficient protocol to induce Ag-specific tolerance...
Keyword:: T cell, Autoimmunity, Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, and Tolerance
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Danielle Marie Turley
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/28/2018
Date Modified:: 08/28/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

Description:: Early-life seizures increase susceptibility to seizures in adulthood. However, mechanisms by which seizures in the developing brain lead to increased vulnerability to seizures and exacerbation of neurological injury in adulthood remain unknown. We test the hypothesis that upregulation of proinflammatory cytokine levels and chronic glial activation following early-life seizures result...
Keyword:: seizures, cytokines, microglia, glia, glutamate, and neuroinflammation
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kathleen Cua Somera-Molina
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/27/2018
Date Modified:: 08/27/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

Mechanisms of RNA Mediated Silencing in S. pombe

Description:: Mechanisms of RNA Mediated Silencing in S. pombe Christina A. Lawrence Heterochromatin of eukaryotic genomes has classically been defined as condensed chromatin that is repressive to transcription and typically resides at highly repetitive regions of the genome. Genetic and molecular analyses have demonstrated that these regions are essential for genome...
Keyword:: heterochromatin, Yeast, epigenetics, and RNAi
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Christina Lawrence
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-05
Resource Type:: Dissertation

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Structural and Functional Analyses of Herpes Simplex Virus Type1 Glycoproteins B and L, Two Essential Components of the Viral Fusogenic Complex

DNA Trafficking in Non-viral Gene Therapy: The Role of the Cytoskeleton

Inhibits Prostate Cancer Cell Motility through Activation of ALK2-Smad1 Signaling

Mechanisms of Oxygen Sensing and Hypoxic Increase in Replicative Lifespan

Estrogen Neuroendocrine Feedback is Mediated Distinctly via Estrogen Response Element Dependent and Independent Estrogen Receptor Alpha Signaling

Stat3-Dependent Survival and Stat3-Independent Terminal Differentiation in the B Cell Compartment in IL-6 Transgenic Mice

N-cadherin Function in Cell Fate Specification of Cortical Precursor Cells

Dual Mechanisms for Antigen-Specific Peripheral Tolerance Induction as a Therapy for Experimental Autoimmune Encephalomyelitis

Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

Mechanisms of RNA Mediated Silencing in S. pombe

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