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Description:: The FDA approvals of afatinib and ibrutinib in 2013 led to a heightened interest in cysteine-reactive covalent inhibitors. However, there are few methods to discover new cysteine-reactive inhibitors for enzymes for which reversible binding scaffolds are not known. To this end, we rationally designed a chemical system to attach a...
Keyword:: Electrophile, Covalent, Fragment, Ubiquitin, and Nedd4-1
Subject:: Chemistry
Creator:: Stefan Kathman
Owner:: Scholarly Digital Publishing
Date Uploaded:: 02/19/2018
Date Modified:: 02/19/2018
Date Created:: 2016-01-01
Resource Type:: Dissertation

Description:: Total synthesis of natural products provides an avenue for investigation of complex chemical scaffolds, not only delivering access to biologically impactful molecules but also lending a deeper understanding of their inherent chemical reactivity. Expansion of reaction methodology, optimization of biological activity, and absolute structural confirmation can all be accomplished via...
Keyword:: allene, total synthesis, peptide, traceless Petasis reaction, natural product, and organic synthesis
Subject:: Organic chemistry and Chemistry
Creator:: Rote, Jennifer
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15164 and etdadmin_upload_750061

Description:: Part 1. The complex folded structures associated with RNA allow for specific protein-RNA interactions and also create binding sites for small molecules. Developing organic molecules that can bind RNA with high affinity and specificity is a challenge that must be overcome for RNA to be considered a viable drug target....
Keyword:: Chemistry
Subject:: Chemistry
Creator:: Graham R Lawton
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/26/2018
Date Modified:: 06/26/2018
Date Created:: 2007-05-03
Resource Type:: Dissertation

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