Index Catalog // Arch : Northwestern University Institutional Repository

Start Over

Filtering by: Subject Biophysics Subject Pharmacology

1 - 2 of 2

List Gallery Masonry Slideshow

Dynamic Mechanisms of Metabotropic Glutamate Receptor Activation and Modulation

Description:

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in humans and play a role in nearly all physiological processes. Among GPCRs, metabotropic glutamate receptors (mGluRs) are a structurally distinct family of synaptic receptors that are essential in regulating neurotransmission and synaptic plasticity. Due to their important regulatory...

Keyword:

structural dynamics, mGluRs, conformational dynamics, membrane proteins, smFRET, and GPCRs

Subject:

Pharmacology, Biochemistry, and Biophysics

Creator:

Liauw, Brandon Wey-Hung

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_937523 and http://dissertations.umi.com/northwestern:16310
Molecular Mechanisms of Orai1 Channel Activation by STIM1

Description:

Store-operated Ca2+ entry through Orai1 channels mediate transcriptional, proliferative, and effector cell programs in many cells and are activated through a unique inside-out mechanism involving binding of the endoplasmic reticulum Ca2+ sensor, STIM1, to cytoplasmic sites on Orai1. Mutations in Orai1 that block channel activation or evoke constitutive channel activity...

Keyword:

Orai1, Gating, STIM1, Channel, CRAC, and Calcium

Subject:

Pharmacology, Biology, and Biophysics

Creator:

Yeung, Priscilla See-Wai

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_622219 and http://dissertations.umi.com/northwestern:14422

LIBRARIES | ARCH

Limit your search

Type

Resource type

Creator

Keyword

Subject

Language

Dynamic Mechanisms of Metabotropic Glutamate Receptor Activation and Modulation

Molecular Mechanisms of Orai1 Channel Activation by STIM1

Limit your search

Search Constraints

Search Results