Investigating the drug response at the transcriptional level is powerful for understanding the mechanism of drug adverse effects, elucidating inter-individual drug response variability and developing personalized therapies. However, drug perturbation experiments are limited to immortal cell lines which do not reflect the true physiology and gene expression of the liver,...
This study examines the impacts of Chicago's Universal Pre-K (UPK) expansion on the operational dynamics of preschools across setting types from the perspective of administrators. Specifically, we explore how Chicago
Public Schools (CPS) principals and and Community-Based Organizations (CBOs) directors experienced the implementation of UPK. Analysis reveals nuanced experiences of...
There are few concerns greater than those of a parent with an adult with an intellectual or developmental disability (I/DD). How is she or he going to be taken care of as she or he ages? The government provides services and support in the pursuit of care and services, but...
With a large sphere of activity and ability to transfer data through wireless communication system, drones have proven to be more and more useful in both research and manufacturing. Whether by allowing researchers to collect measurements or filmmakers to attain aerial shots, the use of drone has allowed collection of...
The bacterial CRISPR/Cas9 system shows promise as a genome-editing tool to treat human disease. It is integral to understand the binding and unbinding kinetics of Cas9 to its target DNA to study specificity of the Cas9 protein. Standard practices involve the use of negatively charged polymer Heparin to reduce unspecific...
Physiological linkage (i.e., the covariation of moment-to-moment physiology between individuals) is thought to play an important role in relationship functioning. The present study examined physiological linkage across interbeat interval (IBI) and skin conductance levels (SCL) in a sample of married spouses (N=106) during both a pleasant and a conflict conversation...
Skeletal sexual dimorphism presents itself in humans primarily through the anatomical shape of the cranium and pelvis. However, some physical anthropologists maintain that climate could have an effect on human sexual dimorphism. Despite ongoing research pertaining to climatic effects on soft tissue or size dimorphism, little to no research has...
A survey of adults (n = 706) found low levels of awareness of two social movements aimed at decreasing weight stigma: the Fat Acceptance Movement and Health at Every Size movement. For HAES, providing a brief story of an overweight person who endorses HAES improved perceptions of the movement.
Recent discoveries of black hole (BH) candidates in galactic and extragalactic globular clusters (GCs) have ignited interest in understanding how BHs dynamically evolve in a GC and the number of BHs (NBH) that may still be retained by today's GCs. Numerical models show that even if stellar-mass BHs are retained...
Polycystic ovary syndrome (PCOS) is a complex genetic disorder characterized by hyperandrogenism, chronic anovulation, and polycystic ovarian morphology. PCOS affects up to 15% of premenopausal women worldwide, is the leading cause of anovulatory infertility, and is a major risk factor for type 2 diabetes. A number of susceptibility loci have...