This thesis presents results and analysis on a series of donor-bridge-acceptor (D-B-A) charge transfer systems in which we use time-resolved spectroscopy and magnetic resonance techniques to study the relationship of molecular structure to energy, charge, and spin transfer dynamics. We find that the sequence of events following the initial charge...
Although non-viral gene therapy has great potential for use in the lung, several problems including inefficient gene transfer and expression and the relative lack of cell-specific targeting have limited its applications. The two approaches that have been used to target genes to desired cell types are through specific ligand-receptor interactions...
Middle childhood is an important but often overlooked developmental period. Similarly, a large literature examines the importance of child care as a developmental context, focusing almost exclusively on pre-school child care experiences. Through three related empirical studies, this dissertation aims to address these two gaps in the extant literature. These...
In this dissertation I examine the relationship between voter turnout and legislative representation in the United States Congress. My main contention is that political elites react to electoral participation in formulating public policies. I posit that the institutional advantages of incumbency in the House of Representative reduces turnout in congressional...
This thesis concerns the development of robust algorithms for large-scale nonlinear programming. Despite recent advancements in high-performance computing power, classes of problems exist that continue to challenge the practical limits of contemporary optimization methods. The focus of this dissertation is the design and analysis of algorithms intended to achieve economy...
NiTi shape memory alloy (SMA) has drawn a great deal of attention for its various applications in the medical field (orthodontics, cardiovascular stents technology, etc.) and in other engineering fields (aerospace, aircraft, automotive, etc.) as it shows shape memory effect, superelasticity and biocompatibility. The fatigue-related issues, however, are pronounced in...
The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting the potential clinical applicability of this technology in regenerative medicine. We hypothesized that this issue is due...
As of 2020, there are currently 5.8 million people in the United States suffering from Alzheimer’s Disease (AD), a debilitating and progressive neurodegenerative disorder. Of these nearly six million people, two-thirds are women. While it has been suggested that women’s longer lifespan accounts for this disparity, the overall lifetime risk...
Most cognitive research on conceptual structure has studied undergraduate populations and either natural (biological) or artificial (experiment-specific) categories. This project investigates how people with extensive, rich knowledge about a complex real-world domain organize and use that knowledge. The research extends prior work on differences among types of experts within biological...
Continuous fiber/epoxy composites have been widely used for structural applications due to their excellent mechanical properties, but the benefits of using these composites is limited by their lower than desired matrix-dominated properties. In this study, epoxy matrix in carbon fiber/epoxy composites was modified with graphite nanoplatelets to improve their mechanical...