Index Catalog // Arch : Northwestern University Institutional Repository

Development of an immunoPET probe to study SARS-CoV-2 pathogenesis in Rhesus Macaques

Description:: Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To...
Subject:: Virology, Cellular biology, and Immunology
Creator:: Madden, Patrick
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15987 and etdadmin_upload_892041

The Role of the Host Response and Viral Genetic Variation in the Pathogenesis of Herpes Simplex Encephalitis

Description:: Herpes simplex virus (HSV) encephalitis (HSE) is the most common cause of sporadic fatal encephalitis, and despite targeted antiviral therapy, outcomes remain poor. While rare in adults, neonates are significantly more susceptible to severe HSV disease. Understanding both the host and viral factors that contribute to pathogenesis is critical to...
Keyword:: Inflammasome, Neonate, Encephalitis, and Herpes
Subject:: Virology, Immunology, and Neurosciences
Creator:: Hayes, Cooper Kincaid
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_903123 and http://dissertations.umi.com/northwestern:16088

Negative Regulation of K63 Polyubiquitination by the Immune Regulator LGP2

Description:: RNA viruses cause a wide range of diseases that range from mild respiratory illness to fatal hemorrhagic fevers. To combat these pathogens, most cells in the human body scan the cell for viruses and activate a potent cell-intrinsic immune response by producing interferon (IFN), a cytokine that amplifies the innate...
Subject:: Virology, Molecular biology, and Cellular biology
Creator:: Lenoir, Jessica
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_866862 and http://dissertations.umi.com/northwestern:15886

The Role of TACC3 in Regulating Microtubule Dynamics During Herpesvirus Infections

Description:: The microtubule (MT) network and associated regulatory proteins play a critical role during viral infection from facilitating viral particle transport towards the nucleus upon entry to later mediating virion assembly and egress. Many of the precise mechanisms by which viruses commandeer the host MT network to propagate infection remain poorly...
Keyword:: TACC3, virus, microtubules, and +TIP
Subject:: Virology, Microbiology, and Cellular biology
Creator:: Furey, Colleen Patricia
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_856328 and http://dissertations.umi.com/northwestern:15823

Phosphorylation of a C-terminal RACK1 Loop by Poxviruses Controls Ribosome Translational Capacity

Description:: Receptor for activated C kinase 1 (RACK1) is a core small (40S) ribosomal subunit protein whose structure is highly conserved among eukaryotes apart from a C-terminal extended loop. We previously showed that a poxvirus kinase phosphorylates this flexible loop in human RACK1, mimicking endogenous negative charge in plant RACK1 to...
Subject:: Virology
Creator:: Rollins, Madeline Grace
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_859919 and http://dissertations.umi.com/northwestern:15843

Immunomodulatory Receptors in Herpes Simplex Virus Pathogenesis

Description:: Herpes simplex virus (HSV) is a ubiquitous human pathogen capable of causing debilitating diseases such as herpes stromal keratitis (HSK) and herpes simplex encephalitis (HSE). Although HSV infection initiates disease pathogenesis, the resulting clinical manifestations are attributed to immunopathological events that occur following viral clearance. To elucidate the molecular mechanisms...
Keyword:: herpes stromal keratitis, herpes simplex encephalitis, herpes simplex virus, herpesvirus entry mediator, and TAM receptors
Subject:: Virology and Immunology
Creator:: Park, Seo Jin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_844174 and http://dissertations.umi.com/northwestern:15730

Role of the Type I IFN Response in Age-dependent Pathogenesis of HSV Encephalitis

Description:: Newborns are particularly susceptible to severe forms of herpes simplex virus type I (HSV-1) infection including encephalitis and multisystemic disseminated disease. The underlying age-dependent differences in the immune response that explain this increased susceptibility relative to the adult population remain largely understudied. Evidence from animal studies and genetic studies in...
Keyword:: Interferon Response, HSV, Neonatal Immunity, and Encephalitis
Subject:: Virology and Immunology
Creator:: Giraldo Perez, Daniel
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15674 and etdadmin_upload_838287

A cellular examination of TLR3 antiviral function in human iPSC-derived CNS and sensory neurons

Description:: Herpes simplex encephalitis (HSE) is a rare and severely debilitating life-threatening disease caused by herpes simplex virus type 1 (HSV-1) infection of the human central nervous system (CNS). The severe and often fatal outcomes of HSE contrast starkly with the more frequent and largely benign consequences of herpes labialis. Whole...
Keyword:: Herpes, PNS, Toll like receptors, TLR3, CNS, and Innate immunity
Subject:: Virology, Microbiology, and Immunology
Creator:: Ewaleifoh, Osefame
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14704 and etdadmin_upload_667366

ISGF3-Mediated Chromatin Dynamics and Regulation of Type I Interferon-Stimulated Genes

Description:: Type I interferon (IFN) is the primary antiviral cytokine establishing a broad and potent antiviral response to protect mammalian cells from virus infection. The functional repertoire of IFN extends to innate and adaptive immunity, neoplastic transformation, resistance and cancer immunotherapy. IFN functions are primarily mediated through the Janus kinase (JAK)...
Keyword:: ISGF3, Interferon, Chromatin, Antiviral, ISG, and H2A.Z
Subject:: Virology, Molecular biology, and Cellular biology
Creator:: Au Yeung, Weng Si (Nancy)
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_618020 and http://dissertations.umi.com/northwestern:14409

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Development of an immunoPET probe to study SARS-CoV-2 pathogenesis in Rhesus Macaques

The Role of the Host Response and Viral Genetic Variation in the Pathogenesis of Herpes Simplex Encephalitis

Negative Regulation of K63 Polyubiquitination by the Immune Regulator LGP2

The Role of TACC3 in Regulating Microtubule Dynamics During Herpesvirus Infections

Phosphorylation of a C-terminal RACK1 Loop by Poxviruses Controls Ribosome Translational Capacity

Immunomodulatory Receptors in Herpes Simplex Virus Pathogenesis

Role of the Type I IFN Response in Age-dependent Pathogenesis of HSV Encephalitis

A cellular examination of TLR3 antiviral function in human iPSC-derived CNS and sensory neurons

ISGF3-Mediated Chromatin Dynamics and Regulation of Type I Interferon-Stimulated Genes

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