Index Catalog // Arch : Northwestern University Institutional Repository

Description:: The insulin/Insulin-Like Growth Factor (IGF) pathway is essential for linking nutritional status to growth and metabolism. MicroRNAs (miRNAs) are short RNAs that are players in the regulation of this process. The miRNA miR-7 shows highly conserved expression in insulin-producing cells across the animal kingdom. However, its conserved functions in regulation...
Keyword:: MicroRNA, Insulin, and Drosophila
Subject:: Molecular biology and Endocrinology
Creator:: Agbu, Pamela
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15272 and etdadmin_upload_764541

Description:: Periodic exposure to light and dark as a result of rotation of the Earth have served as a major evolutionary pressure to partition divergent biological processes to different phases of the day. Mammals display periods of activity/inactivity, wake/sleep, and feeding/fasting during distinct portions of the day. In mammals, these activities...
Subject:: Molecular biology, Medicine, and Endocrinology
Creator:: Levine, Daniel C
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15034 and etdadmin_upload_727063

Description:: The engineering of human reproduction is one of the defining scientific advances of the past century. Methods to specifically engineer the testis have an equally long and rich history, and have experienced significant progress over the past two decades, leading to current-day breakthroughs which are shifting the paradigms by which...
Keyword:: testis, model, organoid, reproduction, microenvironment, and explant
Subject:: Bioengineering, Biology, and Endocrinology
Creator:: Edmonds, Maxwell Ethan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_743728 and http://dissertations.umi.com/northwestern:15119

Description:: Skeletal muscle is one of the most abundant tissues in the body and makes up over 40% of the total body mass. It is important for mobility and posture maintenance as well as plays a central role in whole body metabolism. Skeletal muscle is made up of bundles of muscle...
Keyword:: Muscle plasticity, Genomics, ChIP-seq, and Muscle atrophy
Subject:: Molecular biology and Endocrinology
Creator:: Ramachandran, Krithika
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 04/29/2020
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_718262 and http://dissertations.umi.com/northwestern:14993

Description:: The epidemic of obesity and associated metabolic diseases have led to increased scrutiny of adipose tissue and its primary cell type, the adipocyte. However, studies show that regional adipose tissue distribution rather than obesity per se is a major determinant of metabolic disease risk. Despite having an obese body mass...
Keyword:: Lipogenesis, Insulin Sensitivity, Hypertrophy, Obesity, BCL6, and Adipocyte
Subject:: Biology, Endocrinology, and Genetics
Creator:: Senagolage, Madhavi Dushyanthi
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14575 and etdadmin_upload_658480

Description:: Polycystic ovary syndrome (PCOS) is among the most common endocrine disorders of premenopausal women, affecting 5-15% of this population depending on the diagnostic criteria applied. It is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. PCOS is highly heritable, but only a small proportion of this heritability can be...
Keyword:: complex trait genetics, rare variants, DENND1A, PCOS, and sub-phenotyping
Subject:: Bioinformatics, Genetics, and Endocrinology
Creator:: Dapas, Matthew
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14662 and etdadmin_upload_662808

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