Index Catalog // Arch : Northwestern University Institutional Repository

Nanoparticle therapy for spinal cord injury and the mechanisms regulating fibrotic scarring after spinal cord injury

Description:: Spinal cord injury occurs with a worldwide incidence of 13-33 cases per million per year, and more than 2.5 million patients worldwide suffer from spinal cord injury (SCI)-related disability (1, 2). Different methods have been attempted to promote axonal regeneration, including neurotrophin injection, hydrogel injection, olfactory ensheathing cells implantation and...
Keyword:: Nanotechnology, Cord Injury, Fibrosis, and Therapeutics
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Suji Jeong
Owner:: Scholarly Digital Publishing
Date Uploaded:: 02/08/2019
Date Modified:: 02/09/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Molecular organization of EphA2 cell-cell communication complexes in human keratinocytes

Description:: Erythropoietin-producing human hepatocellular (Eph) receptors and their corresponding ephrin ligands are asymmetrically expressed at cell-cell contacts allowing for bidirectional signaling with forward signaling through the receptor expressing cell and reverse signaling through the ligand expressing cell. Eph receptors are the largest family of receptor tyrosine kinases (RTKs) in mammals, which...
Keyword:: Keratinocyte, Migration, Lipid raft, Eph receptor, Ephrin, and Transmembrane domain
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Rosa Ventrella
Owner:: Scholarly Digital Publishing
Date Uploaded:: 11/25/2019
Date Modified:: 11/25/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Manipulating Exosome Signaling to Inhibit Tumor Metastasis

Description:: Over the past decade significant advancements have been made across the field of cancer biology resulting in transformative new therapies. Despite these advancements, treatments for metastatic cancer remain relatively ineffective. Metastasis is coordinated by various types of â€œhealthyâ€ stromal cells in addition to the tumor cells themselves. This requires a...
Keyword:: Nanotechnology, High-Density Lipoprotein, Cancer Immunology, Pre-Metastatic Niche, Exosomes, and Tumor Microenvironment
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Michael P Plebanek
Owner:: Scholarly Digital Publishing
Date Uploaded:: 11/24/2019
Date Modified:: 11/24/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Regulation of the Cyclic AMP Receptor Protein of Yersinia pestis

Description:: Ubiquitous in the environment are bacteria that have evolved to adapt to the environmental niches they colonize. To this end, bacteria sensory and signaling molecules are required for processing these extracellular changes within their environment into changes in gene expression. The plague-causing pathogen, Yersinia pestis, contains a repertoire of two-component...
Keyword:: Crp, Glucose, Plague, Yersinia, Pla, and Pestis
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Jeremy Todd Henry Ritzert
Owner:: Scholarly Digital Publishing
Date Uploaded:: 11/24/2019
Date Modified:: 11/24/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Function of Discrete MARTX Toxin Domains in Vibrio vulnificus Intragastric Pathogenesis

Description:: In 2015, the United States Department of Agriculture (USDA) reported that 1 in 6 Americans fall ill with a foodborne infection annually, resulting in more than 3000 fatalities and an estimated $15 billion in economic burden due to combined medical costs, productivity loss, and death. On a per-case basis, infections...
Keyword:: bacteria, pathogenesis, vulnificus, toxin, Vibrio, and virulence
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Hannah Gavin
Owner:: Scholarly Digital Publishing
Date Uploaded:: 11/19/2019
Date Modified:: 11/19/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

An Analysis of the Contribution of the Herpesvirus Major Capsid Protein Apical Region Toward Infection

Description:: Herpesvirus virions consist of three layers: nucleocapsid, tegument, and envelope. The innermost layer, the nucleocapsid, initially assembles as an immature procapsid precursor built around viral scaffold proteins. The event that initiates procapsid maturation is unknown but it is dependent upon activation of the internal protease. Scaffold cleavage triggers angularization, or...
Keyword:: maturation, capsid, microscopy, procapsid, herpesvirus, and major capsid protein
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Laura Lee Ruhge
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/28/2019
Date Modified:: 10/28/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

MORPHOLOGY OF THE HINDLIMB AND CORRELATIONS TO LOCOMOTOR TENDENCIES IN PLATYRRHINES

Description:: Platyrrhines are an enigmatic and intriguing radiation of New World monkeys that currently inhabit the western hemisphere from Argentina to Mexico. Platyrrhini, a taxonomic parvorder within Primates, is their formal taxonomic designation, as they represent the sister group of the Catarrhini or all of the Old World monkeys and apes....
Keyword:: Primates, Platyrrhines, Hindlimb Suspension, Leaping, Hindlimb, and Primate Locomotion
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Michael S Mutehart
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/14/2019
Date Modified:: 10/14/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

Description:: Immune checkpoint inhibitors have not been effective for immunologically “cold” tumors, such as prostate cancer, which contain scarce tumor infiltrating lymphocytes. We hypothesized that select tissue-specific and immunostimulatory bacteria can potentiate these immunotherapies. Here we show that a patient-derived prostate-specific microbe, CP1, in combination with anti-PD-1 immunotherapy, increased survival and...
Keyword:: Cancer
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Jonathan Forrest Anker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/22/2019
Date Modified:: 04/22/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Microphysiologic Models of Human Ectocervical Tissue to Study Steroid Hormone Action During Homeostasis, Infection, and Oncogenic Transformation

Description:: There is a shortage of research models that adequately represent the unique mucosal environment of human ectocervical tissue, which has limited the development of new therapies for treating infection or cancer. I hypothesized that engineering the microenvironment of ectocervical tissue with in vivo-like endocrine and paracrine support, would enable squamous...
Keyword:: Cervix, Barrier, Differentiation, Mucins, Estradiol, and Progesterone
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Kelly Elizabeth McKinnon
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/09/2019
Date Modified:: 04/09/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Characterization of Rare Genetic Variation in Polycystic Ovary Syndrome

Description:: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 1 in 10 reproductive-age women and remains the leading cause of female factor infertility among women of childbearing age. PCOS presents with features of hyperandrogenism, irregular menses and polycystic ovaries. Twin and family studies have demonstrated high heritability estimates...
Keyword:: lamin A/C, hyperandrogenism, anti-Mullerian hormone, genetic association, PCOS, and insulin receptor
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Lidija Kristina Gorsic
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/09/2019
Date Modified:: 04/09/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

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Nanoparticle therapy for spinal cord injury and the mechanisms regulating fibrotic scarring after spinal cord injury

Molecular organization of EphA2 cell-cell communication complexes in human keratinocytes

Manipulating Exosome Signaling to Inhibit Tumor Metastasis

Regulation of the Cyclic AMP Receptor Protein of Yersinia pestis

Function of Discrete MARTX Toxin Domains in Vibrio vulnificus Intragastric Pathogenesis

An Analysis of the Contribution of the Herpesvirus Major Capsid Protein Apical Region Toward Infection

MORPHOLOGY OF THE HINDLIMB AND CORRELATIONS TO LOCOMOTOR TENDENCIES IN PLATYRRHINES

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

Microphysiologic Models of Human Ectocervical Tissue to Study Steroid Hormone Action During Homeostasis, Infection, and Oncogenic Transformation

Characterization of Rare Genetic Variation in Polycystic Ovary Syndrome

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