When a cell divides, it must assemble a microtubule-based structure called a spindle, which provides the forces that physically segregate the chromosomes. In most cell types the microtubules that comprise the spindle are nucleated and organized by centriole-containing centrosomes. In many species, however, oocyte meiosis is carried out in the...
On 14 January 2017, President Donald J. Trump described the North Atlantic Treaty Organization (NATO) as obsolete. During the first six months of his administration, President Trump discussed not honoring Article 5 commitments for NATO members who had not met the financial responsibilities outlined in the 2014 Wales Summit. His...
Recent developments have enabled L12-strengthened Co-based superalloys, which have thepotential to surpass Ni-based superalloys as the material of choice for the hottest sections of turbine
blades due to cobalt’s 40 ºC higher melting point. The most-studied branch of Co-based
superalloys are based on the L12 phase Co3(Al,W); however, there is...
Microfluidic technologies enable multi-tissue culture and precise control of media exchange and therefore have significant potential to create more complex in vitro models of reproductive systems, including endocrine cycles. However, microfluidic technologies have largely been applied to gamete-level culture in reproductive biology, with very little progress in organ-level culture. Herein...
Pharmaceutical companies pay more than $2 billion to physicians every year. Most of these payments are for food and beverage, speaking, honoraria, consulting, and travel and lodging, which are termed “general payments.” These payments have come under increased scrutiny as critics of pharmaceutical promotion argue that they influence prescribing in...
South Africa’s rates of mental, neurological, and substance use disorders are among the highest in sub-Saharan Africa. In 2016, the estimated 12-month prevalence for any psychiatric disorder was 16.2%, or approximately 9.1 million individuals. Despite these elevated rates of psychiatric morbidity, access to mental health treatment is poor: only 27%...
From its inception in the early 1900s, vocational education in American high schools was designed to prepare students for jobs that did not require any formal postsecondary education. In the last decades of the 20th century, growing concern about how separating students into “college” and “non-college” tracks often perpetuated racial...
Abstract Kaposi sarcoma (KS) is the most common cancer associated with human immunodeficiency virus/ Acquired Immunodeficiency Syndrome (HIV/AIDS) infection worldwide and it is the most prevalent cancer in some countries in sub-Saharan Africa (SSA). The introduction of combination antiretroviral therapy (ART), led to dramatic declines in KS morbidity and mortality,...
Optical interferometers and resonators are commonly used for precision measurement. These devices can accurately measure the phase shifts of light induced by small changes in the optical path in the device. To meet the need for ultra-sensitive measurement, researchers have developed various approaches to build better and more sensitive devices....
Language is a hallmark of human cognition—a rich and flexible method of representing the world around us. As such, language provides an invaluable resource to human infants: a way of gaining insight into the representations that guide adult cognition. In this dissertation, I explore how language influences infants’ cognition as...