Multiple facets of the natural trajectory of glioma remain poorly understood, which results in a universally poor prognosis for patients with glioma. Many patients with glioma experience tumor-associated epilepsy (TAE) throughout their disease course, but the mechanism by which TAE occurs, who is at continued risk for TAE, and whether...
Fat represents an important source of energy for ovarian cancer (OC) cells and is supplied either through import from the tumor milieu or via de novo lipogenesis. During fast tumor growth, when nutrients are scarce, lipogenesis becomes the primary source of fatty acids. Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in...
NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL). Cells harboring this mutation can become the predominant clone in relapsing disease. We studied the effects of this mutant enzyme...