Skip to Content

Skip to main content

Northwestern University

Parent Unit Name

Login

LIBRARIES | ARCH

Search audio or video

Menu

Login

Deposit Your Work
Browse
About
Help
Contact

Search

Search

Deposit Your Work
Browse
About
Help
Contact

Limit your search

Type

Work13

Resource type

Dissertation10
Dataset2

Creator

Julius B. Lucks2
Kim, Tae-Eun2
Matthew Verosloff2
Adam D. Silverman1
Alexandra Westbrook1
more Creators »

Keyword

synthetic biology[remove]13
cell-free3
cell-free protein synthesis3
biotechnology2
cell-penetrating protein2
more Keywords »

Subject

Bioengineering3
Biology3
Chemical and Biological Engineering3
Chemical engineering3
Biophysics2
more Subjects »

Language

en7
English1

Publisher

MacMillan Publishers1

Search Constraints

Start Over

Filtering by: 2019-01-01 Remove constraint 2019-01-01 Keyword synthetic biology Remove constraint Keyword: synthetic biology

« Previous | 1 - 10 of 13 | Next »

relevance
date uploaded ▼
date uploaded ▲
date modified ▼
date modified ▲

Number of results to display per page

10 per page
20 per page
50 per page
100 per page

View results as:

List Gallery Masonry Slideshow

Search Results

Cell-free Technologies for On-demand Glycoprotein Biomanufacturing and Hands-on Biology Education

Description:

Since their introduction nearly a century ago, protein vaccines and therapeutics have revolutionized our ability to prevent and treat human disease. However, existing production processes for biopharmaceuticals are technically complex and rely on living cells, which necessitates highly centralized manufacturing in large-scale production facilities, specialized equipment, and cold-chain distribution. With...

Keyword:

glycoprotein therapeutics, cell-free protein synthesis, decentralized biomanufacturing, synthetic biology, STEM education, and conjugate vaccines

Subject:

Chemical engineering

Creator:

Stark, Jessica C

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Modified:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_686044 and http://dissertations.umi.com/northwestern:14826
Dissecting the stability determinants of a challenging de novo protein fold and assay development to identify cell-penetrating miniproteins

Description:

This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...

Keyword:

protein design, cell-penetrating protein, protein folding stability, and synthetic biology

Subject:

Biology, Cellular biology, and Biophysics

Creator:

Kim, Tae-Eun

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

08/23/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_1008136 and http://dissertations.umi.com/northwestern:16683
Dissecting the stability determinants of a challenging de novo protein fold and assay development to identify cell-penetrating miniproteins

Description:

This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...

Keyword:

protein design, cell-penetrating protein, synthetic biology, and protein folding stability

Subject:

Biology, Cellular biology, and Biophysics

Creator:

Kim, Tae-Eun

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

08/23/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16695 and etdadmin_upload_1009800
Design and Optimization of a Field-Deployable Biosensing Platform for Measuring Water Quality

Description:

By 2030, up to half of the world’s population is projected to suffer from water insecurity: a chronic scarcity of potable water due to rapidly warming temperatures, increased agricultural demand, and pollution. The health impacts of contaminated water are profound: hundreds of thousands of global deaths each year are ascribed...

Keyword:

diagnostics, water quality, cell-free, and synthetic biology

Subject:

Bioengineering, Chemical engineering, and Public health

Creator:

Silverman, Adam Daniel

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/28/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15551 and etdadmin_upload_817796
Improving and engineering cell-free systems for glycoprotein production

Description:

The need to rapidly develop and produce life-saving vaccines and therapeutics is critical for overcoming pandemics in a global economy. Recent advances in automation and cell-free systems have opened new avenues for expediting optimization and production of biologic vaccines and therapeutics. A key consideration for the development of protein biologics...

Keyword:

biotechnology, bioproduction, glycosylation, vaccines, cell-free protein synthesis, and synthetic biology

Subject:

Chemical engineering

Creator:

Hershewe, Jasmine Marie

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_780613 and http://dissertations.umi.com/northwestern:15396
Model-driven elucidation of synthetic and immune signaling mechanisms

Description:

This dissertation focuses on the development of quantitative approaches for characterizing endogenous signaling pathways and designing new pathways in mammalian cells. I demonstrate how mathematical descriptions that are formulated to explain gene expression patterns can also serve as a powerful springboard for deeper analyses into the properties and functions of...

Keyword:

macrophage, systems biology, receptor, computational biology, transcription factor, and synthetic biology

Subject:

Bioengineering, Molecular biology, and Immunology

Creator:

Muldoon, Joseph Jacob

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15256 and etdadmin_upload_764084
Cell-free Platforms for Synthesis of Non-standard Polypeptides in vitro

Description:

Proteins represent a critical class of biomolecules, universally employed by all living organisms to fulfill essential structural, functional, and enzymatic roles necessary to support life. In nature, these polymers are composed generally of twenty natural amino acid (AA) building blocks, which can be modified with covalent adducts known as post-translational...

Keyword:

post-translational modification, genome engineering, cell-free protein synthesis, synthetic biology, orthogonal translation system, and non-canonical amino acid

Subject:

Bioengineering, Biology, and Biochemistry

Creator:

Des Soye, Benjamin James

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14473 and etdadmin_upload_627384
A Cell-Free Framework for Rapid Enzymatic Pathway Prototyping and Discovery

Description:

It is pertinent now more than ever that we find sustainable alternatives to produce chemicals. For decades, scientists and engineers have turned to biological systems to help meet societal needs in energy, medicine, materials, and moreespecially when chemical synthesis is untenable. Often, biologically-produced small molecules are insufficient for production at...

Keyword:

metabolic engineering, biotechnology, cell-free systems, biosynthetic pathway, synthetic biology, and enzymatic reactions

Subject:

Chemical and Biological Engineering

Creator:

Ashty Karim

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/14/2019

Date Modified:

11/20/2019

Date Created:

2018-01-01

Resource Type:

Dissertation
RNA sequence and structure determinants of Pol III transcriptional termination in human cells

Keyword:

transcription, aptamer, RNA polymerase III, RNA, synthetic biology, and termination

Creator:

Matthew Verosloff, Dr. Julius Lucks, David Bushhouse, Dr. Joshua Leonard, William Corcoran, and Taylor Dolberg

Owner:

Matthew Stuart Verosloff

Date Uploaded:

09/09/2020

Date Modified:

02/15/2021

Resource Type:

Dataset
Design and optimization of a cell-free atrazine biosensor

Description:

Recent advances in cell-free synthetic biology have spurred the development of in vitro molecular diagnostics that serve as effective alternatives to whole-cell biosensors. However, cell-free sensors for detecting manmade organic water contaminants such as pesticides are sparse, partially because few characterized natural biological sensors can directly detect such pollutants. Here,...

Keyword:

biosensor, TX-TL, atrazine, cell-free, cyanuric acid, metabolism, synthetic biology, and transcription factor

Creator:

Umut Akova, Khalid K. Alam, Michael C. Jewett, Julius B. Lucks, and Adam D. Silverman

Owner:

Adam Silverman

Date Uploaded:

09/23/2019

Date Modified:

02/19/2020

« Previous
Next »
1
2

© 2024 Northwestern University
Contact Northwestern University
Careers
Disclaimer
Campus Emergency Information
University Policies

Address
University (Main) Library
1970 Campus Drive
Evanston, IL 60208

Phone number
(847) 491-7658

Email Address
digitalscholarship@northwestern.edu

Libraries Social Media

Facebook Twitter Instagram YouTube

Terms of Use
Support Us
Library Home
Library Jobs
Library Policies
Provide Feedback