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Studies Directed Towards the Total Synthesis of Okilactomycin and Chrolactomycin

Description:

Okilactomycin and chrolactomycin are antitumor antibiotics isolated in 1987 and 2001, respectively. These tetracyclic natural products possess a unique 6-5 fused tetrahydropyrone-butyrolactone. The spirocenter is part of a highly functionalized cyclohexene ring, which together with the aforementioned 6-5 system compose the core of these molecules. A six carbon, 1,3-dialkyl-substituted carbon...

Keyword:

natural products and total synthesis

Subject:

Chemistry

Creator:

William Joseph Morris

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/13/2018

Date Modified:

08/13/2018

Date Created:

2007-06-26

Resource Type:

Dissertation