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Studies in Natural Product Synthesis: Towards (1) Tambromycin and (2) the Solamin Stereoisomers

Description:

Total synthesis of natural products provides an avenue for investigation of complex chemical scaffolds, not only delivering access to biologically impactful molecules but also lending a deeper understanding of their inherent chemical reactivity. Expansion of reaction methodology, optimization of biological activity, and absolute structural confirmation can all be accomplished via...

Keyword:

allene, total synthesis, peptide, traceless Petasis reaction, natural product, and organic synthesis

Subject:

Organic chemistry and Chemistry

Creator:

Rote, Jennifer

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15164 and etdadmin_upload_750061
Development of Chemical Probes for Selective Investigation of Biological Pathways

Description:

Chemical probes are versatile and unique tools for biomedical research. A chemical probe is simply a selective small-molecule modulator of protein function that allows the user to ask mechanistic and phenotypic questions about its molecular target in biochemical, cell-based or animal studies. Experiments involving selective inhibitors can help delineate key...

Keyword:

small molecules, kinases, chemical biology, isoforms, and natural product

Subject:

Chemistry

Creator:

Kristine Deibler

Owner:

Scholarly Digital Publishing

Date Uploaded:

01/10/2019

Date Modified:

01/29/2019

Date Created:

2017-01-01

Resource Type:

Dissertation

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Studies in Natural Product Synthesis: Towards (1) Tambromycin and (2) the Solamin Stereoisomers

Development of Chemical Probes for Selective Investigation of Biological Pathways

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