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Investigations into the Role of RNA Binding Proteins and Alternative Splicing in the Epithelial-Mesenchymal Transition

Description:

The critical importance of alternative mRNA splicing and the RNA binding proteins that orchestrate this essential layer of post-transcriptional gene regulation is increasingly recognized in gene regulatory programs. We and others have shown that alternative splicing plays a causal role during the Epithelial-Mesenchymal transition, a cell-developmental program that is hijacked...

Keyword:

splicing factor, RNA, EMT, alternative splicing, RNA binding protein, and metastasis

Subject:

Bioinformatics and Biology

Creator:

Harvey, Samuel

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14663 and etdadmin_upload_662828
The Perinucleolar Compartment: Studies on Function and Development as a Novel Pan-cancer and Drug Discovery Marker

Description:

The perinucleolar compartment is a nuclear substructure that is associated with, but structurally distinct from the nucleolus. Previous studies have shown that the PNC preferentially forms in cancer cells and PNC prevalence (% of non-mitotic and non-apoptotic cells in a population with one or more PNC) is a prognostic in...

Keyword:

anti-cancer drug, prognostic marker, Perinucleolar comparment, and metastasis

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

John Thomas Norton

Owner:

Jason Christ Chandra

Date Uploaded:

08/30/2018

Date Modified:

08/30/2018

Date Created:

2007-12-10

Resource Type:

Dissertation

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Investigations into the Role of RNA Binding Proteins and Alternative Splicing in the Epithelial-Mesenchymal Transition

The Perinucleolar Compartment: Studies on Function and Development as a Novel Pan-cancer and Drug Discovery Marker

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