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Mechanisms of Acentrosomal Spindle Assembly and Maintenance in C. elegans Oocytes

Description:

Although centrosomes nucleate and organize microtubules in mitotically-dividing cells, spindles in female reproductive cells (oocytes) form in their absence. In some organisms acentrosomal spindle assembly is mediated by acentriolar microtubule organizing centers (MTOCs) that are thought to functionally replace centrosomes. However, spindle assembly in human oocytes does not require MTOCs;...

Keyword:

acentrosomal, meiosis, acentriolar, kinesin, microtubule, and C. elegans

Subject:

Molecular biology, Biochemistry, and Cellular biology

Creator:

Wolff, Ian

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_763687 and http://dissertations.umi.com/northwestern:15248
Spindle Architecture and Chromosome Segregation in Mouse Oocyte Meiosis

Description:

Oocyte meiosis is a specialized, but error prone, form of cell division that is poorly understood. Errors during meiosis often result in aneuploidy, or abnormal chromosome number, that impacts human health and fertility. Aneuploidy is the leading cause of miscarriages and birth defects, such as Down's syndrome in which cells...

Keyword:

chromosome segregation, spindle, meiosis, midzone, oocyte, and anaphase

Subject:

Molecular biology and Cellular biology

Creator:

Heath, Carissa Marie

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_663079 and http://dissertations.umi.com/northwestern:14678

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Mechanisms of Acentrosomal Spindle Assembly and Maintenance in C. elegans Oocytes

Spindle Architecture and Chromosome Segregation in Mouse Oocyte Meiosis

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