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Modeling Epigenetic Dynamics Measured by Mass Spectrometry Using Continuous Time Markov Chains

Description:

Histone methylation plays an important role as an epigenetic regulator, capable of driving stable, persistent changes in gene expression without changing a cell's genetic code. Previous work has used stable isotope labeling (SILAC) in combination with mass spectrometry to observe the relationship between the methylation of two neighboring lysine sites...

Keyword:

mass spectrometry, histone methylation, epigenetics, weighted least squares, and Markov

Subject:

Applied mathematics

Creator:

Yungster, Nir

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_780806 and http://dissertations.umi.com/northwestern:15401
The Design and Application of Novel Biochemical Assays Based on the SAMDI-MS Platform

Description:

SAMDI-MS (Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry) couples the use of chemically-defined self-assembled monolayers of alkane thiolates on gold surfaces with MALDI-TOF mass spectrometry for rapid characterization of the surfaces. Reactions performed on the surfaces can be quantified directly by detection of the reaction substrates and products. This rapid detection...

Keyword:

SAMDI, mass spectrometry, bioassay, chromodomains, cell-free reactions, and microfluidics

Subject:

Analytical chemistry, Materials Science, and Biochemistry

Creator:

O'Kane, Patrick Thomas

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14615 and etdadmin_upload_661860

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Modeling Epigenetic Dynamics Measured by Mass Spectrometry Using Continuous Time Markov Chains

The Design and Application of Novel Biochemical Assays Based on the SAMDI-MS Platform

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