Some of the oldest drugs targeting metabolism are the antifolates such as aminopterin and methotrexate (MTX). MTX started being used in the 1950s to treat rheumatoid arthritis. Aminopterin and MTX both target one carbon metabolism and inhibit proliferation of cells. MTX was a potent inhibitor of inflammation, because it prevented...
Macrophages are one of the most versatile immune cells in the immune system. They are found in nearly every tissue and organ throughout the body. Macrophages play important roles of orchestrating initiation and resolution of inflammation, such as sentineling against pathogens or engulfing apoptotic cells. Macrophages are able to respond...
Herpes stromal keratitis (HSK) is a potentially blinding inflammatory condition initiated by corneal infection with herpes simplex virus (HSV). As its name suggests, the host receptor herpes virus entry mediator (HVEM) facilitates HSV entry through interactions with a viral envelope glycoprotein. HVEM also bridges several signaling networks, binding ligands from...