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The mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Description:

The NLRP3 inflammasome is a multi-protein complex that drives sterile and pathogen-dependent inflammation. Activation of the NLRP3 inflammasome occurs in two steps: priming and activation. Priming occurs in response to an inflammatory stimulus, such as LPS. LPS-primed macrophages are subsequently activated by a second stimuli, most of which require K+...

Keyword:

macrophage, mitochondria, immunometabolism, inflammasome, and metabolism

Subject:

Biology

Creator:

Billingham, Leah Katherine

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15953 and etdadmin_upload_882213
Metabolic Regulation of Allergic Inflammation

Description:

In the United States, allergic disease affects approximately 60 million people and impacts more people every year. While prevalence of allergic disease has steadily increased, there has concurrently been an increase in rates of metabolic syndrome—characterized by increased abdominal girth, decreased sensitivity to insulin, and higher levels of circulating blood...

Keyword:

lung, hyperglycemia, immunometabolism, homeostasis, allergy, and metabolism

Subject:

Biology, Immunology, and Medicine

Creator:

Queener, Ashley

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15602 and etdadmin_upload_824073

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The mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

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