Northwestern University

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Serine metabolism supports macrophage IL-1beta production.

Description:

Some of the oldest drugs targeting metabolism are the antifolates such as aminopterin and methotrexate (MTX). MTX started being used in the 1950s to treat rheumatoid arthritis. Aminopterin and MTX both target one carbon metabolism and inhibit proliferation of cells. MTX was a potent inhibitor of inflammation, because it prevented...

Keyword:

macrophage, LPS, glutathione, metabolism, inflammation, and serine

Subject:

Biology

Creator:

Rodriguez, Arianne

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_638528 and http://dissertations.umi.com/northwestern:14513