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Pedunculopontine Glutamatergic Input to Substantia Nigra Pars Compacta Dopamine Neurons

Description:

In vivo, substantia nigra pars compacta (SNc) dopaminergic neurons exhibit three spiking patterns – irregular, regular, and bursting. These distinct modes of activity are thought to underlie the different roles that dopamine (DA) plays in target structures within the basal ganglia. In particular, burst spiking in SNc DA neurons is...

Keyword:

burst firing, pedunculopontine nucleus, substantia nigra pars compacta, dopamine, and glutamate

Subject:

Interdepartmental Neuroscience Program (NUIN)

Creator:

Daniel James Galtieri

Owner:

Scholarly Digital Publishing

Date Uploaded:

01/16/2019

Date Modified:

01/16/2019

Date Created:

2017-01-01

Resource Type:

Dissertation
Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

Description:

Early-life seizures increase susceptibility to seizures in adulthood. However, mechanisms by which seizures in the developing brain lead to increased vulnerability to seizures and exacerbation of neurological injury in adulthood remain unknown. We test the hypothesis that upregulation of proinflammatory cytokine levels and chronic glial activation following early-life seizures result...

Keyword:

seizures, cytokines, microglia, glia, glutamate, and neuroinflammation

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Kathleen Cua Somera-Molina

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/27/2018

Date Modified:

08/27/2018

Date Created:

2007-12-07

Resource Type:

Dissertation

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Pedunculopontine Glutamatergic Input to Substantia Nigra Pars Compacta Dopamine Neurons

Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

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