Skeletal muscle is a highly sexually dimorphic tissue, with males and females exhibiting differences in muscle size, gene transcription, and metabolism. This thesis describes two models wherein males and females responded to an intervention with the same physiological adaptation but through two distinct mechanisms. In the first model, mice of...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy regimens show high response rates but have debilitating effects and carry risk of relapse. Until now, no targeted therapy has been approved. In addition, 40% of patients will relapse and their treatment options are limited because...
