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Inhibition of amyloid-beta aggregation and toxicity by cobalt(III) Schiff base

Description:

The interaction of amyloid-β (Aβ) with endogenous metal ions is thought to play a role in the pathogenesis of Alzheimer’s disease (AD). However, limited tools exist to study and modulate Aβ-metal binding. The Meade lab has developed cobalt(III) Schiff base (Co(III)-sb) complexes as protein inhibitors that competitively displace metals from...

Keyword:

amyloid-beta, aggregation, cobalt(III) Schiff base, and coordination complex

Subject:

Biology, Biochemistry, and Neurosciences

Creator:

Roberts, Kaleigh Filisa

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_773649 and http://dissertations.umi.com/northwestern:15349
A Gli-Targeted Cobalt Complex and Nanoparticle Delivery Agents for Hedgehog Pathway Inhibition

Description:

Many transcription factors (TFs) regulate oncogenic processes and are therefore desirable targets for drug intervention. However, few TF inhibitors have been developed to date due to a lack of specificity and few TF binding pockets. The Meade Lab has overcome these challenges by using cobalt-based complexes that disrupt Cys2His2 zinc...

Keyword:

cellular delivery, zinc finger, hedgehog pathway, coordination complex, cobalt complex, and transcription factor

Subject:

Nanoscience, Molecular biology, and Chemistry

Creator:

Bajema, Elizabeth Amber

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14453 and etdadmin_upload_626420

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Inhibition of amyloid-beta aggregation and toxicity by cobalt(III) Schiff base

A Gli-Targeted Cobalt Complex and Nanoparticle Delivery Agents for Hedgehog Pathway Inhibition

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