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Enabling Exploration of CAR T-Cell Design and Integration of Social Justice Context into Chemical Engineering Courses

Description:

Chimeric antigen receptor (CAR) T-cell therapies marry advances in cellular engineering with personalized medicine to provide patient-specific, targeted cancer treatments. Though current CAR T-cell therapies successfully target blood cell cancers, treating solid tumors has proven to be more challenging. Solid-tumor CAR designs must overcome several challenges, including tumor microenvironment barriers...

Keyword:

agent-based model, CAR T-cell therapy, social justice, anti-racism diversity equity and inclusion, computational biology, and engineering education

Subject:

Bioengineering, Education, and Chemical engineering

Creator:

Prybutok, Alexis Nicole

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16073 and etdadmin_upload_902739
Model-driven elucidation of synthetic and immune signaling mechanisms

Description:

This dissertation focuses on the development of quantitative approaches for characterizing endogenous signaling pathways and designing new pathways in mammalian cells. I demonstrate how mathematical descriptions that are formulated to explain gene expression patterns can also serve as a powerful springboard for deeper analyses into the properties and functions of...

Keyword:

macrophage, systems biology, receptor, computational biology, transcription factor, and synthetic biology

Subject:

Bioengineering, Molecular biology, and Immunology

Creator:

Muldoon, Joseph Jacob

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15256 and etdadmin_upload_764084

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