Northwestern University

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Filtering by: Keyword biodistribution Keyword spherical nucleic acids Keyword surface modification

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Mapping out the pathways for spherical nucleic acid biodistribution

Description:

Oligonucleotides can be used to modulate the regulation of pathological genes that are associated with various diseases. However, due to biological barriers, efficient delivery of oligonucleotides, especially to extrahepatic tissues, remains a challenge. To overcome these barriers, multiple delivery strategies have been developed, ranging from medicinal chemistry to nanotechnology. Nanoparticle-based...

Keyword:

surface modification, biodistribution, and spherical nucleic acids

Subject:

Chemistry

Creator:

Zhang, Wuliang

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_830130 and http://dissertations.umi.com/northwestern:15627