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Mechanisms of Acentrosomal Spindle Assembly and Maintenance in C. elegans Oocytes

Description:

Although centrosomes nucleate and organize microtubules in mitotically-dividing cells, spindles in female reproductive cells (oocytes) form in their absence. In some organisms acentrosomal spindle assembly is mediated by acentriolar microtubule organizing centers (MTOCs) that are thought to functionally replace centrosomes. However, spindle assembly in human oocytes does not require MTOCs;...

Keyword:

acentrosomal, meiosis, acentriolar, kinesin, microtubule, and C. elegans

Subject:

Molecular biology, Biochemistry, and Cellular biology

Creator:

Wolff, Ian

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_763687 and http://dissertations.umi.com/northwestern:15248