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Description:: One of the fundamental questions in developmental biology is how a single cell gives rise to a complex organism. More specifically, how a totipotent egg divides into cells that become increasingly restricted in their potential. Development is a process of increasingly restricted cellular potential, and here I home in on...
Keyword:: Xenopus, Pluripotency, Neural Default Model, BMP, Smads, and Activin
Subject:: Biology and Developmental biology
Creator:: Johnson, Kristin Lorette
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16347 and etdadmin_upload_945075

Description:: Meiosis is a highly regulated process necessary for proper chromosome division. Zincfluxes regulate mammalian meiosis; between prophase I and metaphase II, total intracellular zinc increases by 50%, while 20% of zinc is released in “zinc sparks” following fertilization. Although zinc fluxes had been shown to be conserved in mammals, it...
Keyword:: Xenopus, Sample Fixation, Zinc, Manganese, Fertilization, and EMI2
Subject:: Inorganic chemistry, Biology, and Biochemistry
Creator:: Seeler, John Frederick
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_819316 and http://dissertations.umi.com/northwestern:15573

Description:: Neural crest cells are a population of multipotent stem cells that are unique to vertebrates and give rise to a wide range of derivatives in the developing embryo, including elements of the craniofacial skeleton, pigmentation of the skin and peripheral nervous system. Although these cells reside in the ectoderm, they...
Keyword:: Xenopus, SoxB1, pluripotency, SoxE, Stem Cells, and Neural Crest Cells
Subject:: Molecular biology and Developmental biology
Creator:: Buitrago-Delgado, Elsy Cristina
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_627223 and http://dissertations.umi.com/northwestern:14468

Description:: It is critical to genomic integrity that DNA is replicated completely and faithfully during each cell cycle. The essential replication factor Cdt1 is a critical protein in preventing reinitiation of replication. Overexpression of Cdt1 causes re-replication in p53 null cells and transforms NIH3T3 cells, causing them to form tumors in...
Keyword:: Xenopus, Cell Cycle, Geminin, Cdt1, and Re-Replication
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Sarah Lynn Kerns
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/01/2018
Date Modified:: 06/01/2018
Date Created:: 2007-05-11
Resource Type:: Dissertation

Description:: The Wnt signalling pathway is used multiple times throughout the development of an organism. Early in embryonic development this path is known to be involved in the induction of the ectodermally derived neural crest. The Wnt pathway is also thought to function in other ectodermal cell types. How the same...
Keyword:: Xenopus, Tcf3, ectoderm, Wnt, neural, and Lef1
Subject:: Interdepartmental Biological Sciences Program
Creator:: Elizabeth Yvette Truesdell
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/09/2018
Date Modified:: 05/09/2018
Date Created:: 2006-12-13
Resource Type:: Dissertation

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