Magnetic nanostructures (MNS) have become the subject of intense
interest due to their superparamagnetic properties and consequently
their potential uses in medical diagnostics and therapeutics. In this
study, monodisperse magnetite MNSs were synthesized via thermal
decomposition of iron(III) acetylacetonate and transferred to aqueous
solution using 11-aminoundecanoic acid as the surfactant....
Neurons are difficult to manipulate experimentally. Most transfection
reagents used for gene silencing are neurotoxic, and the postmitotic
state of neurons prevents the effective use of viral vectors. This study
demonstrated the delivery of antisense DNA against target genes by
gold nanoparticle oligonucleotide complexes (GNOs) in primary cultures
of rat...
This paper investigates the use of self-assembled monolayers
(SAMs) to optimize the localized surface plasmon resonance (LSPR)
biosensor for disease detection. Various experiments were done
with 1-(9-mercaptononyl)-3,6,9-trioxaundecan-11-ol (TDT) and
heptaoxatricosanoic acid (HSA), a new SAM; these included a solvent
study to determine refractive index sensitivity and nonspecific binding
and specific...
This paper reports the syntheses of acetylene-terminated smallmolecule
cores. Also reported are successful attempts at “click”
coupling the core molecules with azide-terminated oligonucleotides to
construct stable small-molecule DNA hybrids (SMDH). Once these
click-based small-molecule DNA hybrids are formed, melting studies
will be done that study how the geometry of SMDH...