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  • Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks

    736664517?file=thumbnail
    Description:
    Over the course of tumor growth, cancer cells interact with normal cells via processes that are difficult to understand by experiment alone. This challenge is particularly pronounced at early stages of tumor formation, when experimental observation is most limited. Eluci-dating such interactions could inform both understanding of cancer and clinical... and Tumor growth involves a dynamic interplay between cancer cells and host cells, which col-lectively form a tumor microenvironmental network that either suppresses or promotes tumor growth under different conditions. The transition from tumor suppression to tumor pro-motion is mediated by a tumor-induced shift in the local immune state, and despite...
    Keyword:
    Tumor formation and Cancer
    Creator:
    Chuang, Yishan , Brockmann, Dirk, Wells, Daniel K. , Leonard, Joshua N., Kath, William L. , and Knapp, Louis M.
    Owner:
    John Dorr
    Language:
    English
    Date Uploaded:
    03/10/2017
    Date Modified:
    05/08/2017
    Date Created:
    2015-04-23
    Resource Type:
    Article
    Alternate Identifier:
    DOI: 10.1371/journal.pcbi.1004181