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Description:: The translation of proteins as effective intracellular drug candidates is limited by the challenge of cellular entry and their vulnerability to degradation. To advance their therapeutic potential, cell-impermeable proteins can be readily transformed into protein spherical nucleic acids (ProSNAs) or encapsulated into liposomal spherical nucleic acids (L-SNAs), structures defined by...
Keyword:: Intracellular Delivery, Enzyme, Spherical Nucleic Acid, Cancer Vaccine, Biologic, and Blood-Brain Barrier
Subject:: Chemistry
Creator:: Kusmierz, Caroline Danielle
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15666 and etdadmin_upload_837502

Description:: Over the past fifty years, techniques for synthesizing and manipulating matter on the 1-100 nanometer scale have led to the development of nanoparticle-based approaches to both disease diagnosis and treatment. The modification of nanoparticles with biological macromolecules such as proteins and nucleic acids has led to the development of highly...
Keyword:: Spherical Nucleic Acid, Anthrax, Aptamer, NanoFlare, Gold Nanoparticle, and CRISPR
Subject:: Nanotechnology, Bioengineering, and Biology
Creator:: Larkin, Isaac Nathaniel
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15186 and etdadmin_upload_754966

Description:: Spherical Nucleic Acids (SNAs) are unique class of nanomaterial characterized by a dense nucleic acid shell conjugated to a nanoparticle core. This radial orientation of oligonucleotides and architecture distinguishes SNAs from the components from which they are comprised. Specifically, unique chemical and biological properties emerge that are not observed with...
Keyword:: Spherical Nucleic Acid, Nanoparticle, Immune system, Toll-like receptors, and Biodistribution
Subject:: Nanotechnology, Chemistry, and Immunology
Creator:: Ferrer, Jennifer R
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14715 and etdadmin_upload_668701

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