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Examining prionogenic domains in the Swi1 protein, yeast evolution, and novel disease-related aggregators

Description:

Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...

Keyword:

[SWI+], yeast, protein aggregation, prions, Saccharomyces cerevisiae, and Swi1

Subject:

Molecular biology, Bioinformatics, and Neurosciences

Creator:

Goncharoff, Dustin Kenneth

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/28/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_816388 and http://dissertations.umi.com/northwestern:15538