The BCR-ABL negative Myeloproliferative Neoplasms (MPNs) are clonal hematopoietic stem-cell disorders characterized by abnormal proliferation of differentiated myeloid lineages. MPNs include 3 clinically distinct disorders: Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF). 95% of MPNs are characterized by driver mutations in Janus Kinase 2 (JAK2), Thrombopoietin receptor...
Prostate cancer (PCa) is the most common non-cutaneous cancer among U.S. men. Lack of effective treatments for advanced disease make it a significant public health concern. However, PCa’s long natural history makes it an excellent target for prevention approaches that reduce overtreatment of indolent disease, treatment related morbidity, and mortality....