Nucleic acid therapeutics can be drug molecules with high programmability, minimal off-target effects, and the capability to address “undruggable” targets for diseases. In addition, each time a new drug is needed, one needs to only change the sequence as opposed to finding an entirely new structure. One nucleic acid type...
Mechanisms of RNA Mediated Silencing in S. pombe Christina A. Lawrence Heterochromatin of eukaryotic genomes has classically been defined as condensed chromatin that is repressive to transcription and typically resides at highly repetitive regions of the genome. Genetic and molecular analyses have demonstrated that these regions are essential for genome...