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Organoids model distinct vitamin E effects at different stages of prostate cancer evolution

Description:

Prostate cancer (PCa) is the most common non-cutaneous cancer among U.S. men. Lack of effective treatments for advanced disease make it a significant public health concern. However, PCa’s long natural history makes it an excellent target for prevention approaches that reduce overtreatment of indolent disease, treatment related morbidity, and mortality....

Keyword:

SELECT, Extracellular matrix, Prostate cancer, Reactive Oxygen Species, Organoids, and Fatty Acid Oxidation

Subject:

Molecular biology, Biology, and Cellular biology

Creator:

Njoroge, Rose Nyawira

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14428 and etdadmin_upload_623433
Perturbations of Epigenetic Events in Prostate Cancer: The Role of TET1, A DNA Demethylase

Description:

FOXA1 is a FKHD family protein that plays pioneering roles in lineage-specific enhancer activation and gene transcription. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically,...

Keyword:

Prostate cancer, TET1, Epigenetics, and FOXA1

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Yeqing (Angela) Yang

Owner:

Scholarly Digital Publishing

Date Uploaded:

03/26/2018

Date Modified:

01/29/2019

Date Created:

2017-01-01

Resource Type:

Dissertation

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Organoids model distinct vitamin E effects at different stages of prostate cancer evolution

Perturbations of Epigenetic Events in Prostate Cancer: The Role of TET1, A DNA Demethylase

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