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Statistical methods for the network-based analysis of genomic data

Description:

The focus of this thesis is on evaluating, designing, and applying statistical methods that elucidate molecular mechanisms by seeking to understand the pathways that contribute to disease. Chapter 1 introduces the field and motivates the work in this thesis. Chapters 2, 3, and 4 describe original work. Chapter 5 recapitulates...

Keyword:

Gene expression, Algorithms, Pathways, Networks, and Systems biology

Subject:

Statistics and Bioinformatics

Creator:

Shah, Sahil D

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14812 and etdadmin_upload_685626
microRNA Regulation of Genes with Genetic Variation and their Systems-Level Consequences in Cancer

Description:

Gene regulatory networks contain multiple components including microRNAs (miRNAs) that coordinate regulation of genes to produce higher level cell functions. miRNAs are small non-coding RNA molecules that modulate gene expression post-transcriptionally by binding to short target motifs on mRNA transcripts to down-regulate target genes. Because miRNA regulation of genes is...

Keyword:

Gene Regulation, Systems Biology, Single Nucleotide Polymorphisms, Pathways, Cancer, and microRNAs

Subject:

Chemical and Biological Engineering

Creator:

Gary Wilk

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/21/2019

Date Modified:

10/21/2019

Date Created:

2018-01-01

Resource Type:

Dissertation

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Statistical methods for the network-based analysis of genomic data

microRNA Regulation of Genes with Genetic Variation and their Systems-Level Consequences in Cancer

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