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Functional characterization of MnSOD and ACSS1 acetylation in metabolism and carcinogenesis

Description:

One of the fundamental observations in oncology is that the rate of cancer malignancy increases with age, which applies to most human malignancies including breast cancer. Therefore, it is crucial to elucidate the mechanistic connection between aging and carcinogenesis. The NAD+-dependent sirtuin family, specifically SIRT3, the primary mitochondrial deacetylase, which...

Keyword:

MnSOD, mitochondria, Sirtuin, cancer, ACSS1, and metabolism

Subject:

Biology

Creator:

Gao, Yucheng

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/28/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15526 and etdadmin_upload_815100
Aberrant acetylation of mitochondrial proteins, due to loss of SIRT3, results in tumor permissive phenotypes and increases breast cancer malignancy risk

Description:

SIRT3 is a mitochondrial-localized, NAD+-dependent deacetylase, tumor suppressor protein that functions to direct mitochondrial energy sensing and antioxidant proteins, increasing the efficiency of energy utilization, providing a redox balanced environment, and preventing aging-related diseases. One SIRT3 deacetylation target is NADP+-dependent isocitrate dehydrogenase 2 (IDH2), a key Krebs Cycle enzyme that...

Keyword:

MnSOD, IDH2, Cancer, and Sirtuins

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Xianghui Zou

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/13/2018

Date Modified:

04/13/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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Functional characterization of MnSOD and ACSS1 acetylation in metabolism and carcinogenesis

Aberrant acetylation of mitochondrial proteins, due to loss of SIRT3, results in tumor permissive phenotypes and increases breast cancer malignancy risk

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