CD99-Like 2 (CD99L2) is a 52 kDa type I glycoprotein expressed on leukocytes and endothelial cells as well as other cell types in mice. It is related to CD99, although it shows only 32% sequence identity. CD99L2 has been shown to play a role in leukocyte extravasation in mice under...
The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...
Fibrosis is a chronic pathology which commonly develops after chronic inflammation. Different specific kinds of inflammation have been linked to fibrosis across various tissues. When specifically occurring in the prostate, fibrosis can lead to urinary dysfunction. Prostate conditions that involve inflammation have also been linked to both prostate fibrosis and...
Inflammasomes are intracellular multiprotein signaling complexes that link Pathogen Associated and Danger Associated Molecular Patterns (PAMPs and DAMPs) by Pattern Recognition Receptors (PRRs) to the activation of Caspase-1, leading to the secretion of pro-inflammatory cytokines interleukin (IL)-1β and IL-18, and the induction of pyroptosis. Nucleotide-binding oligomerization domain (NOD)-like containing a...
Depression in children and adolescents is a prevalent, recurrent, and frequently chronic disorder, representing a considerable public health burden (Birmaher, Ryan, Williamson, Brent, & Kaufman, 2005; Costello et al., 2002). Consequently, an understanding of the disorder is critical for future intervention and prevention efforts. Previous research attempting to clarify family...