Index Catalog // Arch : Northwestern University Institutional Repository

Description:: CD99-Like 2 (CD99L2) is a 52 kDa type I glycoprotein expressed on leukocytes and endothelial cells as well as other cell types in mice. It is related to CD99, although it shows only 32% sequence identity. CD99L2 has been shown to play a role in leukocyte extravasation in mice under...
Keyword:: Inflammation, Transmigration, Leukocyte, PECAM, Endothelial Cell, and CD99-like 2
Subject:: Pathology, Molecular biology, and Immunology
Creator:: Rutledge, Nakisha S
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_903372 and http://dissertations.umi.com/northwestern:16098

Description:: The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...
Keyword:: Inflammation, Hexokinase, Macrophage, Subcellular localization, Metabolism, and Mitochondria
Subject:: Biology
Creator:: De Jesus, Adam
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_773389 and http://dissertations.umi.com/northwestern:15348

Description:: Fibrosis is a chronic pathology which commonly develops after chronic inflammation. Different specific kinds of inflammation have been linked to fibrosis across various tissues. When specifically occurring in the prostate, fibrosis can lead to urinary dysfunction. Prostate conditions that involve inflammation have also been linked to both prostate fibrosis and...
Keyword:: Inflammation, Prostate, Fibrosis, Urinary Dysfunction, Immunology, and Type 2 cytokines
Subject:: Immunology
Creator:: Bell-Cohn, Ashlee
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_742505 and http://dissertations.umi.com/northwestern:15093

Description:: Inflammasomes are intracellular multiprotein signaling complexes that link Pathogen Associated and Danger Associated Molecular Patterns (PAMPs and DAMPs) by Pattern Recognition Receptors (PRRs) to the activation of Caspase-1, leading to the secretion of pro-inflammatory cytokines interleukin (IL)-1β and IL-18, and the induction of pyroptosis. Nucleotide-binding oligomerization domain (NOD)-like containing a...
Keyword:: Inflammation, Inflammasome, Gout, Innate immune response, NLRP3, and NLRP11
Subject:: Biology
Creator:: Gangopadhyay, Anu
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15043 and etdadmin_upload_731489

Description:: Depression in children and adolescents is a prevalent, recurrent, and frequently chronic disorder, representing a considerable public health burden (Birmaher, Ryan, Williamson, Brent, & Kaufman, 2005; Costello et al., 2002). Consequently, an understanding of the disorder is critical for future intervention and prevention efforts. Previous research attempting to clarify family...
Keyword:: Inflammation, Empathy, Families, Consistency, and Depression
Subject:: Clinical Psychology
Creator:: Erika Manczak
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/18/2018
Date Modified:: 04/18/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

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