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The Role of the Host Response and Viral Genetic Variation in the Pathogenesis of Herpes Simplex Encephalitis

Description:

Herpes simplex virus (HSV) encephalitis (HSE) is the most common cause of sporadic fatal encephalitis, and despite targeted antiviral therapy, outcomes remain poor. While rare in adults, neonates are significantly more susceptible to severe HSV disease. Understanding both the host and viral factors that contribute to pathogenesis is critical to...

Keyword:

Inflammasome, Neonate, Encephalitis, and Herpes

Subject:

Virology, Immunology, and Neurosciences

Creator:

Hayes, Cooper Kincaid

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_903123 and http://dissertations.umi.com/northwestern:16088
NLRP11 is Essential for NLRP3 Inflammasome Activation

Description:

Inflammasomes are intracellular multiprotein signaling complexes that link Pathogen Associated and Danger Associated Molecular Patterns (PAMPs and DAMPs) by Pattern Recognition Receptors (PRRs) to the activation of Caspase-1, leading to the secretion of pro-inflammatory cytokines interleukin (IL)-1β and IL-18, and the induction of pyroptosis. Nucleotide-binding oligomerization domain (NOD)-like containing a...

Keyword:

Inflammation, Inflammasome, Gout, Innate immune response, NLRP3, and NLRP11

Subject:

Biology

Creator:

Gangopadhyay, Anu

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

01/21/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15043 and etdadmin_upload_731489

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The Role of the Host Response and Viral Genetic Variation in the Pathogenesis of Herpes Simplex Encephalitis

NLRP11 is Essential for NLRP3 Inflammasome Activation

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