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Engineering the "Nanocarrier Chassis" for Targeted Drug Delivery: Controllable Multiscale Interactions for Immunomodulation and Glaucoma Therapy

Description:

Nanocarriers are drug delivery vehicles that have at least one dimension at the nanoscale (10-9 m). Engineering the nanocarrier surface is a strategy for targeting drug delivery to specific cell types to enhance efficacy and minimize side effects. A useful analogy is to consider how the chassis of an automotive...

Keyword:

Nanotechnology, Glaucoma, Immunomodulation, Protein Adsorption, Nanocarrier Chassis, and Targeted Drug Delivery

Subject:

Pharmaceutical sciences, Materials Science, and Biomedical engineering

Creator:

Vincent, Michael Patrick

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15870 and etdadmin_upload_863441
Development of Biomaterial Scaffolds to Modulate the Local Immune Microenvironment and Support Allogeneic Islet Transplantation

Description:

Intrahepatic islet transplantation is a promising therapeutic option for the treatment of Type-1 diabetes that offers the ability to restore endogenous insulin production. Widespread use of islet transplantation is currently limited by poor survival of transplanted islets due to the harsh environment of the liver portal vein, prompting investigation into...

Keyword:

Immunomodulation, Biomaterials, Localized Delivery, and Islet Transplantation

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Jeffrey Mao-Hwa Liu

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/22/2018

Date Modified:

10/22/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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Engineering the "Nanocarrier Chassis" for Targeted Drug Delivery: Controllable Multiscale Interactions for Immunomodulation and Glaucoma Therapy

Development of Biomaterial Scaffolds to Modulate the Local Immune Microenvironment and Support Allogeneic Islet Transplantation

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