A major distinction among different skeletal muscles in the human body is the number, size, and arrangement of its cells, referred to as a muscle’s architecture. Muscle architecture is indicative of a muscle’s ability to contract and produce force and, like muscle function, is plastic. While neuromuscular plasticity is the...
Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
Connecting structure and function in nanoscale engineered materials and devices relies on the analysis of the fundamental arrangement of matter, frequently under dynamic conditions. The demand to image structures at fundamental length scales has touched inorganic materials, biology, and frequently hybrid hard/soft materials with unique phenomena driven by heterogeneous components....