Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Mammalian transcriptional regulation is well-known to be complex and highly context dependent. Different genetic and epigenetic features, including single nucleotide polymorphisms (SNPs) that function as cis- or trans-expression quantitative trait loci (eQTLs), transcription factor (TF) interaction profile with cis-regulatory elements (CREs), methylation of CpG dinucleotide sequences, and histone modification that...
Keyword:: Bioinformatics, Transcriptomics, Gene regulation, Deep Learning, Machine Learning, and Drug discovery
Subject:: Bioinformatics, Genetics, and Oncology
Creator:: Ji, Yanrong
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_818497 and http://dissertations.umi.com/northwestern:15562

Description:: Nucleic acids not only are the building blocks of life but also a class of attractive macromolecular therapeutics. However, the delivery of therapeutic oligonucleotides into cells has been a major challenge due to their large size and highly negatively charged backbone. Spherical nucleic acids (SNAs) are a class of emerging...
Keyword:: Nanomedicine, Gene regulation, and Drug delivery
Subject:: Materials Science, Biomedical engineering, and Chemical engineering
Creator:: Zhu, Shengshuang
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_672179 and http://dissertations.umi.com/northwestern:14728

Description:: Certain inducible genes show faster reactivation if they were recently expressed. This epigenetic phenomenon is called transcriptional memory and is inherited for several generations after the first round of induction. During this phase, genes show several conserved molecular features that are essential for faster reactivation: peripheral localization of the gene,...
Keyword:: Epigenetic memory, Adaptive fitness, Genome organization, Evolution, Gene regulation, and GAL genes
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Varun Sood
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/11/2019
Date Modified:: 01/11/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

LIBRARIES | ARCH