Northwestern University

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Antiglioma Activity of Bimodal cGAS-Agonistic and STAT3-Inhibitiory Spherical Nucleic Acids

Description:

Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...

Keyword:

GBM, Spherical nucleic acids, cGAS, Immunotherapy, and STING

Subject:

Biology, Biochemistry, and Immunology

Creator:

Mahajan, Akanksha Sanjay

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

05/31/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_983546 and http://dissertations.umi.com/northwestern:16516