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Epstein-Barr Virus Glycoprotein 42: The Dynamic Trigger of B-cell Membrane Fusion

Description:

Epstein-Barr virus (EBV) is a human herpesvirus that is able to infect both epithelial cells as well as B lymphocytes, where the virus stablishes life-long latency in the host. Five glycoproteins are involved in infection of B cells: gp350/220 for initial tethering of the virus to the cell via CD21,...

Keyword:

membrane fusion, inhibitory peptide, viral entry, Epstein-Barr virus, gp42, and herpesviruses

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Amanda Renee Kim Eun-Ja Silva Lowrey

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/20/2018

Date Modified:

09/20/2018

Date Created:

2008-12-01

Resource Type:

Dissertation
Structural and functional characterization and inhibition of Epstein-Barr virus fusion proteins gH, gL, and gp42

Description:

Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and is associated with the etiology of several human cancers of lymphoid and epithelial cell origin, including Burkitt's lymphoma and nasopharyngeal carcinoma. It is an extremely prevalent virus in human populations worldwide. All herpesviruses, including EBV, infect cells by fusing the...

Keyword:

membrane fusion, peptide inhibitior, antiviral, viral entry, Epstein-Barr virus, and glycoprotein structure

Subject:

Interdepartmental Biological Sciences Program

Creator:

Austin Kirschner

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/27/2018

Date Modified:

08/27/2018

Date Created:

2007-08-15

Resource Type:

Dissertation

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Epstein-Barr Virus Glycoprotein 42: The Dynamic Trigger of B-cell Membrane Fusion

Structural and functional characterization and inhibition of Epstein-Barr virus fusion proteins gH, gL, and gp42

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