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Sub-diffusion and Compartmentalization: How the Nuclear Pore Complex and Stochastic Movement are Utilized to Dynamically Organize the Eukaryotic Genome

Description:

In nearly all Eukaryotes, the membrane-enclosed nucleus contains the vast majority of the cellular genome. Within this sub-cellular compartment, the nuclear architecture facilitates genomic chromatin organization. Controlling chromosomal loci’s spatial positioning relative to subnuclear structures and each other can have local and global effects on gene expression. Moreover, chromatin organization...

Keyword:

Genome, Yeast, Statistics, Nucleus, Epigenetics, and Diffusion

Subject:

Molecular biology, Genetics, and Biophysics

Creator:

Sumner, Michael Chas

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15670 and etdadmin_upload_837750