Northwestern University

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Filtering by: Keyword DOT1L Keyword Prostate Cancer

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Histone Methyltransferase DOT1L Coordinates AR and MYC Stability in Prostate Cancer

Description:

The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is implicated in active transcription. Here we show that DOT1L is overexpressed in Prostate cancer (PCa) and is associated with poor clinical outcome. Genetic and chemical inhibition of DOT1L selectively impaired viability of androgen receptor (AR)-signaling competent PCa...

Keyword:

Prostate Cancer, DOT1L, and Epigenetics

Subject:

Molecular biology and Oncology

Creator:

Vatapalli, Rajita

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

04/29/2020

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14971 and etdadmin_upload_714534