Northwestern University

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Filtering by: Keyword Colorectal cancer Keyword DNA repair defects Keyword Genomic instability

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Dissecting the diverse phenotypes and pathological impacts of neutrophils in colitis-to-CRC progression

Description:

Tissue-infiltrating neutrophils (polymorphonuclear neutrophils [PMNs]) are a prominent feature of inflammatory bowel disease (IBD) and colorectal cancer (CRC), where these immune cells can promote cytotoxicity or exacerbate disease outcomes. We recently showed that in acute colon injury, PMNs can increase DNA double-strand break (DSB) burden and promote genomic instability via...

Keyword:

Neutrophils, DNA repair defects, Neutrophil heterogeneity, Tumor angiogenesis, Colorectal cancer, and Genomic instability

Subject:

Pathology, Oncology, and Immunology

Creator:

Bui, Triet M

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_872984 and http://dissertations.umi.com/northwestern:15896